On Saturday, Spiritwood RCMP responded to a home on the Pelican Lake First Nation due to an altercation.
Other emergency services also responded to the scene including EMS.
RCMP say it was reported that an adult had suffered life-threatening injuries.
Once crews arrived, it was determined that a man had died from his injuries.
One suspect has been arrested and is in custody.
An autopsy is set to take place in Saskatoon Tuesday.
Charged in the second degree murder of Dustin Chamakese is Lorin Chamakese of the Pelican Lake First Nation.
The victim and accused are related.
Chamakese will appear in Spiritwood Provincial Court Tuesday.
The investigation is continuing.